EYE OF SCIENCE/SCIENCE … Furthermore, microscopy lacks adequate sensitivity to evaluate efficacy of treatment in … Saving Lives, Protecting People, Resources for Health Professionals: Treatment, Division of Parasitic Diseases and Malaria, U.S. Department of Health & Human Services. To evaluate the effects of antischistosomal drugs, used alone or in combination, for treating S. mansoni infection. To aid in our quest to develop treatments, two studies undertook molecular investigations of the parasite Schistosoma mansoni . Schistosomiasis is caused by a parasitic flatworm about which little is known. Schistosoma mansoni est un ver plat parasite, appartenant à l’embranchement des Plathelminthes (vers plats non segmentés), à la classe des Trématodes (appareil digestif avec cæcum), à l’ordre des Strigeatida (ventouses ventrale et buccale), la famille des Schistosomatidés (cercaires libres) et enfin au genre Schistosoma, car l’hôte définitif est un mammifère. Abstract objective To assess the efficacy and side effects of praziquantel in the treatment for Schistosoma mansoni infection in school children in Senbete Town, northeastern Ethiopia. … In children aged less than 5 years, there is limited evidence that these doses may be less effective, and further research will help optimise the dose for this age-group. Oxamniquine, a largely discarded alternative, also appears effective. In trials reporting clinical improvement evaluating lower doses (20 mg/kg and 30 mg/kg) against the standard 40 mg/kg for both praziquantel or oxamniquine, no dose effect was demonstrable in resolving abdominal pain, diarrhoea, blood in stool, hepatomegaly, and splenomegaly (follow up at one, three, six, 12, and 24 months; three trials, 655 participants). A simplified combination of human mass treatment with oxamniquine and focal snail control has been applied in a local Schistosoma mansoni control programme in a primary health care setting in the Dalati and Agallu Metti areas of the Ethiopian Blue Nile Valley. The results show that a single dose of praziquantel (40 mg/kg), as recommended by the World Health Organization, is an effective treatment for Schistosoma mansoni infection. DOI: 10.1002/14651858.CD000528.pub2, Copyright © 2020 The Cochrane Collaboration. Preventive treatment, which should be repeated over a number of years, will reduce and prevent morbidity. Most trials report on whether or not the treatment stops eggs excretion; three reported the persons recovery from symptoms. The long-term, in vivo effects of a single, subcurative dose (200 mg/kg body weight of mouse) of praziquantel on the structure of adult Schistosoma mansoni and on the process and speed of tegumental repair are described. IL‐10 levels following stimulation with PHA (A, 3 day cultures), soluble egg antigen (SEA) (B) and soluble worm antigen preparation (SWAP) (C) (5 day cultures) at baseline for children who were all Schistosoma mansoni egg‐positive, and after 4 mass drug administrations (MDAs) (post‐MDA group) in children who were either S. mansoni egg‐negative or egg‐positive. Compared to placebo, oxamniquine 40 mg/kg probably reduces parasitological treatment failure at three months (RR 8.74, 95% CI 3.74 to 20.43, two trials, 82 participants, moderate quality evidence). Parasitologists United Journal 5, 147 – 154. Page last reviewed: April 11, 2018. More on: Resources for Health Professionals: Treatment. Inside the host, the larvae grow into adult worms; these produce eggs, which are excreted in the faeces. 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